Benji Curtis, Dylan Riley and Jake Martin broke open a 4-3 game with third-period goals for Pictou County, who also saw Keven Larouche, Mark Kennedy and Drew Packman collect tallies.
Andrew Shewfelt, Julian Makary and Connor Vermeulen replied for Amherst.
The Crushers host the Miramichi Timberwolves on Sunday at 7 p.m.